Lorenzaccio (Lorenzino de Medicis), 1514-1548
نویسندگان
چکیده
منابع مشابه
Dmd051680 1514..1521
The purpose of this study was to evaluate the impact of intestinal efflux transporters on the in vivo oral absorption process. Three model drugs—fexofenadine (FEX), sulfasalazine (SASP), and topotecan (TPT)—were selected as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and P-gp and BCRP substrates, respectively. The drugs were orally administered to portal vein– cannulated rat...
متن کاملAndreas Vesalius (1514-1564).
For some reason Jacob Sylvius, crossed with him and remained his enemy till the end. Vesalius was professor of anatomy at Padua for some time. Sylvius had condemned his former student as a "madman whose pestilential teachings were poisoning Europe". When he was discredited, even by his other colleagues and students, he left Padua, at the age of 30, never to return again. He accepted an invitati...
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Hox genes are critical regulators of skeletal development and Hox9-13 paralogs, specifically, are necessary for appendicular development along the proximal to distal axis. Loss of function of both Hoxa11 and Hoxd11 results in severe malformation of the forelimb zeugopod. In the radius and ulna of these mutants, chondrocyte development is perturbed, growth plates are not established, and skeleta...
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For drugs with hepatobiliary transport across hepatocytes, the interplay between uptake and efflux transporters determines hepatic concentrations of drugs, but the evolution over time of these concentrations is difficult to measure in humans other than with magnetic resonance imaging contrast agents in the liver. Gadobenate dimeglumine (BOPTA) is a contrast agent used in liver magnetic resonanc...
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Sleep apnoea hypopnoea syndrome (SAHS) is characterized by periodic apnoea that is associated with cyclical changes in arterial oxygen saturation (SaO2). In SAHS, Hasday and Grum [1] were the first to measure the overnight change of urinary uric acid secretion and report that it could be a good index of tissue hypoxia. However, the validation of this index has not been confirmed by subsequent s...
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ژورنال
عنوان ژورنال: The American Historical Review
سال: 1905
ISSN: 0002-8762
DOI: 10.2307/1834732